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Archer, Stephen
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Concept Altitude Sickness
Concept Aortic Valve Stenosis
Concept Antibody Specificity
Concept Electric Stimulation
Concept Carcinoma, Non-Small-Cell Lung
Concept Cell Separation
Concept Immune System
Concept Diet Surveys
Concept Drug Synergism
Concept Cytochrome P-450 Enzyme System
Concept Educational Status
Concept Health Surveys
Concept Long QT Syndrome
Concept Mass Screening
Concept Cross-Sectional Studies
Concept Disease Susceptibility
Concept Muscle, Smooth
Concept Genes, Dominant
Concept Fatty Acids, Unsaturated
Concept Feasibility Studies
Concept Dietary Fats, Unsaturated
Concept Health Services Accessibility
Concept Iron-Sulfur Proteins
Concept Mitral Valve Stenosis
Concept Organ Size
Concept Muscle, Smooth, Vascular
Concept Heat-Shock Proteins
Concept Herpes Simplex
Concept Nervous System Diseases
Concept Safety
Concept Persistent Fetal Circulation Syndrome
Concept Sulfones
Concept Pre-Excitation Syndromes
Concept Research Support as Topic
Concept Prostaglandin-Endoperoxide Synthases
Concept Vasomotor System
Concept Serotonin Antagonists
Concept Wolff-Parkinson-White Syndrome
Concept Somatostatin
Concept Species Specificity
Concept Cohort Studies
Concept Scleroderma, Systemic
Concept Smoking
Concept Spectrum Analysis
Concept Sarcoidosis
Concept Serotonin
Concept Sensitivity and Specificity
Concept Swine
Concept Sheep
Concept Silver
Concept Societies, Medical
Concept Tomography, Emission-Computed, Single-Photon
Concept Single-Blind Method
Concept Superoxides
Concept Specific Pathogen-Free Organisms
Concept Training Support
Concept Cardiology Service, Hospital
Concept Ultrasonography
Concept United States
Concept Stroke Volume
Concept Superoxide Dismutase
Concept Ubiquinone
Concept Sex Distribution
Concept Myocardial Stunning
Concept Uncoupling Agents
Concept Protein Subunits
Concept Up-Regulation
Concept Lupus Erythematosus, Systemic
Concept Chi-Square Distribution
Concept Rats, Sprague-Dawley
Concept Case-Control Studies
Concept Genes, Reporter
Concept National Institutes of Health (U.S.)
Concept Oxidative Stress
Concept Simvastatin
Concept Dietary Sucrose
Concept Calcium Signaling
Concept Metabolic Syndrome
Concept Romano-Ward Syndrome
Concept Cross-Over Studies
Concept SOXF Transcription Factors
Concept Reactive Oxygen Species
Concept Sirtuin 3
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Sexual Dysfunctions, Psychological
Concept 5' Untranslated Regions
Concept Oligonucleotide Array Sequence Analysis
Concept 3' Untranslated Regions
Concept Sirolimus
Concept Prostaglandins, Synthetic
Concept Surveys and Questionnaires
Concept Rats, Inbred Strains
Concept Scorpion Venoms
Concept Serine
Concept Serum Albumin
Concept Severity of Illness Index
Concept Myocytes, Smooth Muscle
Concept Schools, Medical
Concept Substance P
Concept Sulfhydryl Reagents
Concept Sulfonamides
Concept Sulfur
Concept Nitric Oxide Synthase Type II
Concept High-Throughput Nucleotide Sequencing
Concept Mitochondrial Size
Concept Staphylococcus aureus
Concept Stereoisomerism
Concept STAT2 Transcription Factor
Concept Survival Analysis
Concept Patient Satisfaction
Concept Ion-Selective Electrodes
Concept Genome, Human
Concept Survival Rate
Concept Free Radical Scavengers
Concept Hypoplastic Left Heart Syndrome
Concept Cellular Senescence
Concept Dietary Supplements
Concept Gene Silencing
Concept Nitric Oxide Synthase
Concept Hepatopulmonary Syndrome
Concept Coronary Stenosis
Concept Extracellular Signal-Regulated MAP Kinases
Concept Shal Potassium Channels
Concept Transcriptome
Concept Nutritional Sciences
Concept Genome-Wide Association Study
Concept Secondary Prevention
Concept RNA, Small Interfering
Concept Ribosomal Protein S6 Kinases, 70-kDa
Concept Intracellular Signaling Peptides and Proteins
Concept Nitric Oxide Synthase Type III
Concept National Heart, Lung, and Blood Institute (U.S.)
Concept Follow-Up Studies
Concept Longitudinal Studies
Concept Prospective Studies
Concept Rats, Mutant Strains
Concept Retrospective Studies
Concept Sincalide
Concept Syncope
Concept Systole
Concept Signal Transduction
Concept Polymorphism, Single Nucleotide
Concept Shab Potassium Channels
Academic Article Superoxide dismutase: an antireductant enzyme?
Academic Article Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue.
Academic Article Postischemic oxygen radical production varies with duration of ischemia.
Academic Article The non specificity of specific nitric oxide synthase inhibitors.
Academic Article Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia.
Academic Article Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension.
Academic Article Chronic infusion of nitric oxide in experimental pulmonary hypertension: pulmonary pressure-flow analysis.
Academic Article A placebo-controlled trial of prostacyclin in acute respiratory failure in COPD.
Academic Article Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel.
Academic Article Diversity of response in vascular smooth muscle cells to changes in oxygen tension.
Academic Article Activation of the cGMP-dependent protein kinase mimics the stimulatory effect of nitric oxide and cGMP on calcium-gated potassium channels.
Academic Article Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel.
Academic Article Ventilation-induced pulmonary vasodilation at birth is modulated by potassium channel activity.
Academic Article Acute hypoxic pulmonary vasoconstriction: a model of oxygen sensing.
Academic Article The somatostatin analog angiopeptin does not reduce chronic hypoxic pulmonary hypertension in rats.
Academic Article Aerosol delivery of diethylenetriamine/nitric oxide, a nitric oxide adduct, causes selective pulmonary vasodilation in perinatal lambs.
Academic Article Potassium channel diversity in vascular smooth muscle cells.
Academic Article Utility of a nitric oxide electrode for monitoring the administration of nitric oxide in biologic systems.
Academic Article Sildenafil: from the bench to the bedside.
Academic Article Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology.
Academic Article In memoriam : Francis X. Witkowski.
Academic Article Alterations in a redox oxygen sensing mechanism in chronic hypoxia.
Academic Article Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes.
Academic Article Pulmonary vasoconstriction, oxygen sensing, and the role of ion channels: Thomas A. Neff lecture.
Academic Article A maturational shift in pulmonary K+ channels, from Ca2+ sensitive to voltage dependent.
Academic Article Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5.
Academic Article Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension.
Academic Article Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction.
Academic Article Redox control of oxygen sensing in the rabbit ductus arteriosus.
Academic Article Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2+, independent of membrane potential.
Academic Article Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats.
Academic Article GTP (gammaS) and GDP (betaS) as electron donors: new wine in old bottles.
Academic Article Dexfenfluramine elevates systemic blood pressure by inhibiting potassium currents in vascular smooth muscle cells.
Academic Article Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Academic Article O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.
Academic Article Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation.
Academic Article Triple-bonded unsaturated fatty acids are redox active compounds.
Academic Article Voltage-gated potassium channels in human ductus arteriosus.
Academic Article Case 2. Recurrence of myocardial infarction.
Academic Article Gene transfer and metabolic modulators as new therapies for pulmonary hypertension. Increasing expression and activity of potassium channels in rat and human models.
Academic Article The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies.
Academic Article Sildenafil reverses O2 constriction of the rabbit ductus arteriosus by inhibiting type 5 phosphodiesterase and activating BK(Ca) channels.
Academic Article In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats.
Academic Article Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels.
Academic Article Innovative strategic Canadian research training from TomorrOw's Research Cardiovascular Health Care Professionals (TORCH).
Academic Article Cellular and molecular pathobiology of pulmonary arterial hypertension.
Academic Article Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide.
Academic Article Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition.
Academic Article The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels.
Academic Article Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension.
Academic Article Canadian Cardiovascular Society and Canadian Thoracic Society position statement on pulmonary arterial hypertension.
Academic Article Acute oxygen-sensing mechanisms.
Academic Article An evidence-based approach to the management of pulmonary arterial hypertension.
Academic Article Pre-B-cell colony-enhancing factor regulates vascular smooth muscle maturation through a NAD+-dependent mechanism: recognition of a new mechanism for cell diversity and redox regulation of vascular tone and remodeling.
Academic Article Measurement of endothelial cytosolic calcium concentration and nitric oxide production reveals discrete mechanisms of endothelium-dependent pulmonary vasodilatation.
Academic Article Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization.
Academic Article Canadian Cardiovascular Society and Canadian Thoracic Society position statement on pulmonary arterial hypertension.
Academic Article The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.
Academic Article An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.
Academic Article Images in cardiovascular medicine. Untreated 37-year-old homozygous familial hypercholesterolemic smoker.
Academic Article Association of education with dietary intake among young adults in the bi-ethnic Coronary Artery Risk Development in Young Adults (CARDIA) cohort.
Academic Article Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension.
Academic Article The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension.
Academic Article Enhanced chemiluminescence as a measure of oxygen-derived free radical generation during ischemia and reperfusion.
Academic Article The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted.
Academic Article Dilated cardiomyopathy and left bundle branch block associated with ingestion of colloidal gold and silver is reversed by British antiLewisite and vitamin E: the potential toxicity of metals used as health supplements.
Academic Article Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells.
Academic Article O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide.
Academic Article Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells.
Academic Article Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus.
Academic Article ZK 36-374, a stable analog of prostacyclin, prevents acute hypoxic pulmonary hypertension in the dog.
Academic Article Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung disease.
Academic Article Carbon monoxide diffusing capacity and mortality in pulmonary arterial hypertension.
Academic Article Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension.
Academic Article Cardiac EASE (Ensuring Access and Speedy Evaluation) - the impact of a single-point-of-entry multidisciplinary outpatient cardiology consultation program on wait times in Canada.
Academic Article Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation.
Academic Article The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.
Academic Article Detection of activated O2 species in vitro and in rat lungs by chemiluminescence.
Academic Article A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension.
Academic Article Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.
Academic Article Counterpoint: Hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen species.
Academic Article Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies.
Academic Article Diagnosis and management of pulmonary hypertension in systemic sclerosis.
Academic Article The role of redox changes in oxygen sensing.
Academic Article Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.
Academic Article A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Academic Article A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion.
Academic Article Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
Academic Article Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Academic Article Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association.
Academic Article Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension.
Academic Article Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus.
Academic Article ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association.
Academic Article The association between erectile dysfunction and peripheral arterial disease as determined by screening ankle-brachial index testing.
Academic Article Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia.
Academic Article Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH.
Academic Article Myocardial damage in patients with sarcoidosis and preserved left ventricular systolic function: an observational study.
Academic Article Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung.
Academic Article Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle.
Academic Article Lung ¹8F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension.
Academic Article Hypoxic pulmonary vasoconstriction is unaltered by creatine depletion induced by dietary beta-guanidino propionic acid.
Academic Article Association of serum creatinine with abnormal hemodynamics and mortality in pulmonary arterial hypertension.
Academic Article Paracrine proliferative signaling by senescent cells in world health organization group 3 pulmonary hypertension: age corrupting youth?
Academic Article Chronic primary and secondary thromboembolic pulmonary hypertension.
Academic Article Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension.
Academic Article The effects of substance P on the preconstricted pulmonary vasculature of the anesthetized dog.
Academic Article Pulmonary endarterectomy surgery--a technically demanding cure for WHO Group IV Pulmonary Hypertension: requirements for centres of excellence and availability in Canada.
Academic Article Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure.
Academic Article Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells.
Academic Article Aetiology and management of male erectile dysfunction and female sexual dysfunction in patients with cardiovascular disease.
Academic Article Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor.
Academic Article Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats.
Academic Article Value of exercise treadmill testing in the risk stratification of patients with pulmonary hypertension.
Academic Article Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.
Academic Article Five-year follow-up of a multicenter, double-blind randomized clinical trial of laparoscopic Nissen vs anterior 90 degrees partial fundoplication.
Academic Article The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.
Academic Article A KCNE1 missense variant (V47I) causing exercise-induced long QT syndrome (Romano Ward).
Academic Article Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Academic Article Superoxide reduction of a disulfide: a model of intracellular redox modulation?
Academic Article Exercise thallium testing in ventricular preexcitation.
Academic Article Comparison of the hemodynamic effects of nitric oxide and endothelium-dependent vasodilators in intact lungs.
Academic Article Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats.
Academic Article Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.
Academic Article Effect of graded hypoxia on the induction and function of inducible nitric oxide synthase in rat mesangial cells.
Academic Article Redox status in the control of pulmonary vascular tone.
Academic Article Dithionite increases radical formation and decreases vasoconstriction in the lung. Evidence that dithionite does not mimic alveolar hypoxia.
Academic Article Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells.
Academic Article Effects of dietary fish oil on lung phospholipid fatty acid composition and intrinsic pulmonary vascular reactivity.
Academic Article Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study.
Academic Article A redox-based O2 sensor in rat pulmonary vasculature.
Academic Article Identification of opioid receptors in the immune system using a novel combination of selective opioid ligands and indirect phycoerythrin immunofluorescence.
Academic Article Chronic hypoxic pulmonary hypertension. Is thrombin involved?
Academic Article Cellular and molecular basis of pulmonary arterial hypertension.
Academic Article Simultaneous measurement of O2 radicals and pulmonary vascular reactivity in rat lung.
Academic Article The mitochondrion as a Swiss army knife: implications for cardiovascular disease.
Academic Article Diversity of phenotype and function of vascular smooth muscle cells.
Academic Article Effect of dietary fish oil on lung lipid profile and hypoxic pulmonary hypertension.
Academic Article Late gadolinium enhancement cardiovascular magnetic resonance predicts clinical worsening in patients with pulmonary hypertension.
Academic Article Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction.
Academic Article NG-monomethyl-L-arginine causes nitric oxide synthesis in isolated arterial rings: trouble in paradise.
Academic Article The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels.
Academic Article A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension.
Academic Article The measurement of NO in biological systems using chemiluminescence.
Academic Article Potassium channels regulate tone in rat pulmonary veins.
Academic Article Diversity in mitochondrial function explains differences in vascular oxygen sensing.
Academic Article O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor.
Academic Article Use of sildenafil for safe improvement of erectile function and quality of life in men with New York Heart Association classes II and III congestive heart failure: a prospective, placebo-controlled, double-blind crossover trial.
Academic Article Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop.
Academic Article Hypoxic pulmonary vasoconstriction.
Academic Article Usefulness of mean aortic valve gradient and left ventricular diastolic filling pattern for distinguishing symptomatic from asymptomatic patients.
Academic Article Pergolide is an inhibitor of voltage-gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction.
Academic Article A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system.
Academic Article Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.
Academic Article Pathways of proliferation: new targets to inhibit the growth of vascular smooth muscle cells.
Academic Article ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association.
Academic Article A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension.
Academic Article Epigenetic mechanisms of pulmonary hypertension.
Academic Article Pulmonary and systemic nitric oxide measurements during CCK-5-induced panic attacks.
Academic Article PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension.
Academic Article QTc prolongation is associated with impaired right ventricular function and predicts mortality in pulmonary hypertension.
Academic Article Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment.
Academic Article FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
Academic Article Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.
Academic Article The role of redox signaling in epigenetics and cardiovascular disease.
Academic Article GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.
Academic Article Relationship between changes in dietary sucrose and high density lipoprotein cholesterol: the CARDIA study. Coronary Artery Risk Development in Young Adults.
Academic Article Differences in food habits and cardiovascular disease risk factors among Native Americans with and without diabetes: the Inter-Tribal Heart Project.
Academic Article Atrioventricular heart block and syncope coincident with diagnosis of systemic lupus erythematosus.
Academic Article Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission.
Academic Article Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model.
Academic Article SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress.
Academic Article Persistence of complex vascular lesions despite prolonged prostacyclin therapy of pulmonary arterial hypertension.
Academic Article Noninvasive cardiac output measurements in patients with pulmonary hypertension.
Academic Article Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
Academic Article Abnormal angiogenesis in blood outgrowth endothelial cells derived from von Willebrand disease patients.
Academic Article A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.
Academic Article Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.
Academic Article Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications.
Academic Article Soluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Academic Article Survival in pulmonary hypertension due to chronic lung disease: Influence of low diffusion capacity of the lungs for carbon monoxide.
Academic Article Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities.
Academic Article Trends and Outcomes of Pulmonary Arterial Hypertension-Related Hospitalizations in the United States: Analysis of the Nationwide Inpatient Sample Database From 2001 Through 2012.
Academic Article Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension.
Academic Article Mitochondrial dynamics--mitochondrial fission and fusion in human diseases.
Academic Article Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.
Academic Article Association of dietary fish and n-3 fatty acid intake with hemostatic factors in the coronary artery risk development in young adults (CARDIA) study.
Academic Article Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension.
Academic Article Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension.
Academic Article An official American Thoracic Society Statement: pulmonary hypertension phenotypes.
Academic Article Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Academic Article The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease.
Academic Article The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure.
Academic Article Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension.
Academic Article Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.
Academic Article [Relevant issues in the pathology and pathobiology of pulmonary hypertension].
Academic Article Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.
Academic Article Gone fission: an asymptomatic STAT2 mutation elongates mitochondria and causes human disease following viral infection.
Academic Article MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype.
Academic Article Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society.
Academic Article Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research.
Academic Article Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension.
Academic Article Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension.
Academic Article The first Keystone Symposia Conference on pulmonary vascular isease and right ventricular dysfunction: Current concepts and future therapies.
Academic Article Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.
Academic Article A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus.
Academic Article Relevant issues in the pathology and pathobiology of pulmonary hypertension.
Academic Article Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada.
Academic Article A Step Closer to Understanding How Riociguat Results in Remodelling of the Right Ventricle in Chronic Thromboembolic Pulmonary Hypertension.
Academic Article Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.
Academic Article Clinical Determinants and Prognostic Implications of Right Ventricular Dysfunction in Pulmonary Hypertension Caused by Chronic Lung Disease.
Academic Article Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.
Academic Article Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat.
Academic Article Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.
Academic Article Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction".
Academic Article Home Virtual Visits for Outpatient Follow-Up Stroke Care: Cross-Sectional Study.
Academic Article Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes.
Academic Article Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
Academic Article Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes.
Academic Article An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Academic Article Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension.
Academic Article Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension.
Academic Article Mitochondria in the Pulmonary Vasculature in Health and Disease: Oxygen-Sensing, Metabolism, and Dynamics.
Academic Article Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
Academic Article Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion.
Academic Article Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema: Therapeutic Implications.
Academic Article Providing care for the 99.9% during the COVID-19 pandemic: How ethics, equity, epidemiology, and cost per QALY inform healthcare policy.
Academic Article Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling.
Academic Article Evaluation of the Impact of an Echocardiographic Diagnosis of Pulmonary Hypertension on Patient Outcomes.
Academic Article Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
Academic Article Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice.
Academic Article Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.
Academic Article Scientist on the Spot: Exploring the cause and cure for pulmonary arterial hypertension.
Academic Article Hemodynamic Characteristics and Outcomes of Pulmonary Hypertension in Patients Undergoing Tricuspid Valve Repair or Replacement.
Academic Article Left Main Coronary Artery Compression in Pulmonary Arterial Hypertension: Percutaneous Treatment to Improve Symptoms.
Academic Article Corrigendum to: Scientist on the spot: Exploring the cause and cure for pulmonary arterial hypertension.
Academic Article The molecular mechanisms of oxygen-sensing in human ductus arteriosus smooth muscle cells: A comprehensive transcriptome profile reveals a central role for mitochondria.
Academic Article Carvedilol for Treatment of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
Academic Article PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension.
Academic Article Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop.
Academic Article Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology.
Academic Article Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility.
Academic Article Mitochondria in human neutrophils mediate killing of Staphylococcus aureus.
Academic Article Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra-coronary aortic banding.
Academic Article The comprehensive transcriptome of human ductus arteriosus smooth muscle cells (hDASMC).
Academic Article Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.
Academic Article Using health administrative data to identify patients with pulmonary hypertension: A single center, proof of concept validation study in Ontario, Canada.
Academic Article SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.
Academic Article An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats.
Academic Article A Multi-omic and Multi-Species Analysis of Right Ventricular Failure.
Academic Article Effect of Chronic Digoxin Use on Mortality and Heart Failure Hospitalization in Pulmonary Arterial Hypertension.
Concept Sildenafil Citrate
Concept Soluble Guanylyl Cyclase
Grant Impaired mitochondrial fusion in pulmonary arterial hypertension
Grant O2 sensing in the human and rabbit ductus arteriosus.
Grant EDRF IN NORMAL AND HYPERTENSIVE PULMONARY VASCULATURE
Grant The Role of DRP-1 and Mitochondrial Fission in Pulmonary Arterial Hypertension
Academic Article Asymptomatic surveillance testing for COVID-19 in health care professional students: lessons learned from a low prevalence setting.
Academic Article Using omics to breathe new life into our understanding of the ductus arteriosus oxygen response.
Academic Article Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site IQ Is Crucial for Oxygen Sensing in Rabbit and Human Ductus Arteriosus.
Academic Article Multi-omic and multispecies analysis of right ventricular dysfunction.
Academic Article The Herpes Simplex Virus pUL16 and pUL21 Proteins Prevent Capsids from Docking at Nuclear Pore Complexes.
Academic Article Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury.
Academic Article Germline and Somatic Mutations in DNA Methyltransferase 3A (DNMT3A) Predispose to Pulmonary Arterial Hypertension (PAH) in Humans and Mice: Implications for Associated PAH.
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